-353-THE ROLE OF CARDIAC ADRENERGIC RECEPTORS IN CARDIOMYOPATHIC BIO 14.6 SYRIAN HAMSTERS
نویسندگان
چکیده
منابع مشابه
Stimulatory Protein in Cardiomyopathic BIO 53.58 Syrian Hamsters
Background The effects of chronic exercise training on myocardial contractility and ,B-adrenergic signal transduction in hearts with left ventricular dysfunction have not been determined. Methods and Results Fourteen-week-old cardiomyopathic BIO 53.58 and normal F1B Syrian hamsters underwent 10 weeks of treadmill training and were compared with 24-weekold BIO 53.58 and F1B untrained controls. L...
متن کاملInefficient muscarinic transduction in cardiomyopathic Syrian hamsters.
Regulation of cyclic AMP (cAMP) production and muscarinic binding were studied in highly washed left ventricular membranes from spontaneously cardiomyopathic Syrian hamsters (TO strain). Basal production of cAMP was decreased relative to that in random-bred (RB) controls, with proportionally similar decreases in stimulated production elicited by 7 beta-deacetyl-7 beta-(gamma-N-methylpiperazino)...
متن کاملChronic dynamic exercise improves a functional abnormality of the G stimulatory protein in cardiomyopathic BIO 53.58 Syrian hamsters.
BACKGROUND The effects of chronic exercise training on myocardial contractility and beta-adrenergic signal transduction in hearts with left ventricular dysfunction have not been determined. METHODS AND RESULTS Fourteen-week-old cardiomyopathic BIO 53.58 and normal F1B Syrian hamsters underwent 10 weeks of treadmill training and were compared with 24-week-old BIO 53.58 and F1B untrained contro...
متن کاملCardiomyopathic Hamsters
The mechanism by which heart cells of cardiomyopathic (CM) hamsters become calcium overloaded is not known. We examined the number of slow calcium channels, calcium uptake via slow calcium channels, calcium pool sizes, and the contractile response to Bay K 8644, verapamil, and nifedipine using isolated cardiac myocytes from 8-9-month-old CM hamsters (BIO 14.6) and age-matched normal controls. T...
متن کاملAbnormality in plasma catecholamines and myocardial adrenoceptors in cardiomyopathic BIO 53.58 Syrian hamsters and improvement by metoprolol treatment.
The catecholaminergic neuronal activity and the densities of alpha-1 and beta adrenoceptors and angiotensin II receptors were simultaneously determined in BIO 53.58, a model of idiopathic dilated cardiomyopathy, and F1B control hamsters. Further, we examined the effect of repeated p.o. administration of metoprolol on these biochemical parameters. Compared with F1B control hamsters, there was a ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 1986
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.50.565_1